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Wednesday, July 29, 2020 | History

1 edition of Neurochemical and behavioral tolerance to cocaine following treatment with cocaine analogs found in the catalog.

Neurochemical and behavioral tolerance to cocaine following treatment with cocaine analogs

by Tobias Tong-Po Lee

  • 110 Want to read
  • 5 Currently reading

Published by s.n.] in [New Haven, Conn .
Written in English

    Subjects:
  • Medicine

  • Edition Notes

    Thesis (M.D.) - Yale University, 1998.

    Statementby Tobias Tong-Po Lee
    The Physical Object
    Pagination45 leaves ;
    Number of Pages45
    ID Numbers
    Open LibraryOL26388685M
    OCLC/WorldCa689666974

    Psychostimulant drugs include cocaine, amphetamine, methamphetamine, methylphenidate, and nicotine. Behavioral sensitization, an animal model for addiction to this class of drugs [,], is a process by which the same dose of drug produces increasing degrees of Cited by: Neurobiology of Relapse to Heroin and Cocaine Seeking. of Share & Embed.

    Research Assistant II, Harvard Medical School/New England Regional Primate Research Center, School of Medicine, Department of Behavioral Biology: - Research Assistant, University of Massachusetts - Amherst, Department of Psychology: - Teaching Assistant, University of Massachusetts - Amherst, Department of Zoology: - In addition, the effects of lorcaserin treatment were also observed with larger doses of cocaine, suggesting that the monkeys were unable to surmount the effects of lorcaserin by taking more cocaine. This is excellent news for Dr. Collins and the France lab, suggesting great promise for lorcaserin in the treatment of cocaine abuse.

    Chemotherapy-induced cognitive impairment, known also as “chemobrain”, is a medical complication of cancer treatment that is characterized by a general decline in cognition affecting visual and verbal memory, attention, complex problem solving skills, and motor function. It is estimated that one-third of patients who undergo chemotherapy treatment will experience cognitive impairment. depression levels in cocaine extinction mice, accompanied by a significant upregulation of miR level specifically in the ventral hippocampus (vHP). In parallel, some potential target genes of miR related synaptic plasticity and neurochemical environment, including BDNF and CREB are markedly reduced in the vHP. As expected, synaptic.


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Neurochemical and behavioral tolerance to cocaine following treatment with cocaine analogs by Tobias Tong-Po Lee Download PDF EPUB FB2

Analogs of benztropine (BZT) that, like cocaine, act at the DAT have effects that differ from cocaine and in some situations block the behavioral, neurochemical, and reinforcing actions of cocaine.

Cocaine dependence is an unrelenting public health concern worldwide. Data from the USA indicate that approximately 2 million Americans over the age of 12 years report current cocaine use [].Inprimary cocaine abuse accounted for 13% of treatment admissions in the USA according to the Treatment Episode Data Set [].In the EU, approximately million people report current cocaine use [].

Few studies BASIC PHARMACOLOGICAL MECHANISMS OF COCAINE 1 1 have looked at opioid effects on cocaine pharmacology. Naloxone (an opioid an­ tagonist) has been reported to have no effect on cocaine toxicity, even though mor­ phine will potentiate the number of seizures produced by cocaine (Derlet, Tseng, Tharratt, & Albertson, ).Cited by: 4.

Cocaine. Cocaine is a naturally occurring alkaloid in the leaves of the coca plant, Erythroxylon coca, which is indigenous to the Andean region of South area of coca under cultivation in Colombia, Peru and Bolivia peaked in athectares, subsequently declining tohectares in Cited by: Aiko Ikegami, Christine L.

Duvauchelle, in International Review of Neurobiology, C Plasma and Brain Cocaine Levels: Sensitization. The progressive enhancement of activity by the same dose of a psychostimulant, such as cocaine, is known as behavioral sensitization or reverse tolerance (e.g., McKim, ; Post and Rose, ).Neural mechanisms underlying behavioral sensitization after.

Pure or pharmaceutical grade cocaine is prepared by initial hydrolysis of the total base extract to obtain l-ecgonine from which cocaine is resynthesized by esterification first with methanol, then with benzoic acid.

The second method for purification is that reported to be done in the coca-producing areas and involves acid extraction.

These stimulant effects often occur in conjunction with feelings of euphoria, a combination that has led to the widespread abuse of amphetamine and its analogs, including a pure form of methamphetamine known as “ice,” which emerged on the recreational drug scene in the late s (Cho, ).Cited by: 3.

Genetics and Clinical Neurobiology of Drug Addiction --High Potency Cocaine Analogs: Neurochemical, Imaging, and Behavioral Studies / J.W. Boja [and others] --Methamphetamine-induced Neurotoxicity: Structure Activity Relationships / Mark S. Kleven and Lewis S.

Seiden --Genetic Determinants of Ethanol Reinforcement / John C. Crabbe [and others. Drug tolerance is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use.

Increasing its dosage may re-amplify the drug's effects; however, this may accelerate tolerance, further reducing the drug's effects. Abstract. Cocaine is a naturally occurring alkaloid extracted from the leaves of the South American shrub Erythroxylon European explorers reported the habit of chewing of coca leaves by native populations, and systematic investigations of the effects of cocaine were conducted in the late nineteenth century by Sigmund Freud and by: @article{osti_, title = {Comparative behavioral pharmacology and toxicology of cocaine and its ethanol-derived metabolite, cocaine ethyl-ester (cocaethylene)}, author = {Katz, J L and Terry, P and Witkin, J M}, abstractNote = {The present study compared the behavioral and toxic effects of cocaine and its ethanol derived metabolite, cocaine ethyl-ester (cocaethylene).

Differential Influence of Dopamine Transport Rate on the Potencies of Cocaine, Amphetamine, and Methylphenidate.

Segal, D., Kuczenski, R., O'Neil, M. et al. Escalating Dose Methamphetamine Pretreatment Alters the Behavioral and Neurochemical Profiles Associated with Exposure to a High-Dose Methamphetamine by: Glucagon-like-peptide-1 (GLP-1) and its long acting analogs comprise a novel class of type 2 diabetes (T2D) treatment.

What makes them unique among other T2D drugs is their concurrent ability to reduce food intake, a great benefit considering the frequent comorbidity of T2D and obesity. The precise neural site of action underlying this beneficial effect is vigorously by: Crack, smokeable, is $5-$20 for intoxicating doses.

Cocaine was in coca-cola until under the Pure Food & Drug Act. It is still flavored by decocained extracts. Freud used to treat own depression. He wrote the cocaine papers. He prescribed cocaine to other patients until the health risks became known.

Contact Triad Technology Center Cassell Drive Room Baltimore, MD Phone: Email: [email protected] INTRODUCTION. The Centers for Disease Control and Prevention (CDC) has officially declared prescription drug overdose deaths epidemic in the United States (U.S.).

1 The National Survey on Drug Use and Health estimated that million Americans were living with prescription opioid use disorder andwere addicted to heroin.

2 In addition to opioids available by prescription. The D2 receptor antagonist haloperidol inhibits the development of behavioral sensitization to cocaine Sensitization is believed to play an important role in drug craving and the reinstatement of compulsive drug-taking behav94 thus, altered regulation of D2 receptors may contribute to the reinforcing potential of cocaine/5.

Decreased reinforcing effects of cocaine following 2 weeks of continuous D-amphetamine treatment in rats. Psychopharmacology ,– (). Crossref, Medline, CAS, Google ScholarCited by: NIDA - Director's Report - September [11/17/16, PM] File Size: 1MB. Heroin overdose is a medical emergency that requires treatment with naloxone.

Call for an emergency transport in the US and Canada. Call for an emergency transport in the US and Canada. Signs of an opioid overdose include extreme drowsiness, blue lips and fingernails, slow or halted breathing, pinpoint pupils, slow heart rate, coma, death.An occasion of drug taking may be a passing indulgence of an adolescent, perhaps initiated in a moment of immature judgment.

All too often, the drug taking can become repetitive and may lead to a syndrome of abuse or addiction, possibly in an interaction of inherited vulnerability traits with environmental conditions and processes. The development of addiction and the dependence syndrome in.Ecological momentary assessment of relapse to substance use following treatment MOORE, TODD UNIVERSITY OF TENNESSEE KNOXVILLE Behavioral Determinants of Cocaine Tolerance BRANCH, MARC UNIVERSITY OF FLORIDA Nicotinic Modulation of Methamphetamine's Behavioral and Neurochemical Effects.